In gentle of these observations, sirtuins are recognised as novel regulators of immuno-metabolism in humans. Apart from SIRT1, SIRT2 is lately associated with cytoskeleton reworking and activation of NLRP3 in intracellular pathways[117]. Apart from the activation of innate immunity, the contribution of adaptive immune cells in inducing inflammation is now https://www.directivepublications.org/journal-of-diabetology-research/