Chemotherapy was potentiated by E7449 and solitary agent experienced major antitumor activity in BRCA-deficient xenografts. Moreover, E7449 inhibited Wnt/β-catenin signaling in colon most cancers mobile traces, most likely by TNKS inhibition. Per this risk, E7449 stabilized axin and TNKS proteins leading to β-catenin de-stabilization and appreciably altered expression of Wnt https://saddams641jot5.blognody.com/profile