Limb-threatening or important limb ischemia (CLI) is manifested by Persistent (more than two weeks) ischemic relaxation agony, ischemic wounds or tissue reduction, or gangrene in one or both equally legs. Ischemic relaxation agony generally occurs soon soon after falling asleep; the affected person is awakened by burning soreness or numbness https://www.sgvascularctr.com/treatment-of-peripheral-artery-disease-pad-in-singapore-a-comprehensive-guide/