From the LSD-certain crystal framework, the side chain on the lid residue L209EL2 kinds intensive hydrophobic contacts with each LSD and bordering residues in TMs III, IV, and V (Figure 4C). Once the lid moved aside to expose the binding pocket in simulation, a number of of those contacts broke. https://holdenavogy.mycoolwiki.com/7944248/facts_about_limited_edition_exclusive_lsd_crystal_revealed