Should you be allergic to any ingredient from the syrup, or Should you have had an allergic response on getting an analogous or similar medicine before, it's best to avoid the cough syrup that contains codeine. The intraperitoneal LD50 in rats is 170mg/kg As well as in mice is 160mg/kg. https://socialwebconsult.com/story5541373/the-best-side-of-coughs-syrup