Study into conolidine has led to discovery of an opioid receptor in your body called ACKR3/CXCR7. ACKR3 appears to be one of the most sought after concentrate on for conolidine, which also disregards one other 4 classical opioid receptors(3). Conolidine has long been located in the tabernaemontana divaricata plant, https://www.proleviate.com/post/conolidine-an-alternative-natural-pain-relief-to-replace-traditional-painkillers